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It is reduced by glutathione reductase (GR) using nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) as an electron donor
Compared with full basal-bolus insulin regimens, the combination of GLP-1 agonist plus insulin resulted in a marginal 0.1% reduction in HbA1c, a 33% lower risk of hypoglycaemia and a mean 5.66-kg reduction in weight
In theory, the difference in the effects might be attributed to a limited set of upstream and downstream effector proteins in erythrocytes compared with nucleated cells [84]
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